Abstract: Isimo se-microbial se-fermenter sinomthelela omkhulu kwikhwalithi kabhiya.Ukuhlanzeka nokungabi namagciwane kuyisidingo esiyisisekelo sokuphathwa kwenhlanzeko ekukhiqizeni ubhiya.Uhlelo oluhle lwe-CIP lungakwazi ukuhlanza isivundisi ngempumelelo.Izinkinga zomshini wokuhlanza, indlela yokuhlanza, inqubo yokuhlanza, i-ejenti yokuhlanza/ukukhethwa kwe-sterilzant kanye nekhwalithi yokusebenza kohlelo lwe-CIP kwaxoxwa ngakho.
Isandulelo
Ukuhlanza nokuvala inzalo kuwumsebenzi oyisisekelo wokukhiqiza ubhiya kanye nesilinganiso esibaluleke kakhulu sobuchwepheshe sokuthuthukisa ikhwalithi kabhiya.Inhloso yokuhlanza nokuvala inzalo ukususa ukungcola okukhiqizwe udonga lwangaphakathi lwamapayipi kanye nemishini ngesikhathi sokukhiqiza, nokuqeda usongo lokonakala kwama-microorganisms ekukhiqizeni ubhiya.Phakathi kwazo, isitshalo sokuvutshelwa sinezidingo eziphakeme kakhulu zama-microorganisms, futhi umsebenzi wokuhlanza nokuvala inzalo ungaphezu kuka-70% wawo wonke umsebenzi.Njengamanje, umthamo we-fermenter uya ngokuya uba mkhulu, futhi ipayipi elidlulisa impahla liya liba lide futhi lide, okuletha ubunzima obuningi ekuhlanzeni nasekuvaleni inzalo.Indlela yokuhlanza nokubulala amagciwane ngendlela efanele nangempumelelo ukuze kuhlangatshezwane nezidingo zamanje “zamakhemikhali ezinto eziphilayo” zikabhiya futhi kuhlangatshezwane nezidingo zomthengi zekhwalithi yomkhiqizo kufanele kuqashwe kakhulu ngabasebenzi abaphisa ubhiya.
Indlela yokuhlanza engu-1 nezinto ezihlobene nazo ezithinta umphumela wokuhlanza
1.1 indlela yokuhlanza
Ngesikhathi senqubo yokukhiqiza ubhiya, ingaphezulu lezinto zokusebenza ezithinta impahla izofaka ukungcola okuthile ngezizathu ezihlukahlukene.Kuma-fermenters, izakhi ezingcolile ziwukungcola imvubelo namaprotheni, ama-hops nama-hop resin compounds, namatshe kabhiya.Ngenxa kagesi omile nezinye izici, lokhu kungcola kunamandla athile okukhangisa phakathi kodonga lwangaphakathi lwe-fermenter.Ngokusobala, ukuze ukhiphe ukungcola odongeni lwethangi, inani elithile lamandla kufanele likhokhwe.La mandla angaba amandla emishini, okungukuthi, indlela yokukhuhla ukugeleza kwamanzi enamandla athile omthelela;amandla amakhemikhali angasetshenziswa futhi, njengokusebenzisa i-ejenti yokuhlanza ene-asidi (noma i-alkaline) ukukhulula, ukuqhekeka noma ukuhlakaza ukungcola, ngaleyo ndlela kushiye indawo enamathiselwe;Kungamandla ashisayo, okungukuthi, ngokukhulisa izinga lokushisa lokuhlanza, ukusheshisa ukusabela kwamakhemikhali nokusheshisa inqubo yokuhlanza.Eqinisweni, inqubo yokuhlanza ngokuvamile iwumphumela wenhlanganisela yemiphumela yemishini, amakhemikhali kanye nezinga lokushisa.
1.2 Izinto ezithinta umphumela wokuhlanza
1.2.1 Inani le-adsorption phakathi kwenhlabathi nengaphezulu lensimbi lihlobene nobulukhuni obungaphezulu bensimbi.Uma ingaphezulu lensimbi liqina, kuqina ukukhangiswa phakathi kokungcola nendawo, futhi kuba nzima kakhulu ukuyihlanza.Izisetshenziswa ezisetshenziselwa ukukhiqiza ukudla zidinga i-Ra<1μm;izici zezinto ezingaphezulu zemishini nazo zithinta ukukhangiswa phakathi kokungcola nobuso bezinto zokusebenza.Isibonelo, ukuhlanzwa kwezinto zokwenziwa kunzima kakhulu uma kuqhathaniswa nokuhlanzwa kwensimbi engagqwali.
1.2.2 Izici zokungcola nazo zinobudlelwano obuthile nomthelela wokuhlanza.Ngokusobala, kunzima kakhulu ukususa ukungcola okudala okomisiwe kunokukhipha okusha.Ngakho-ke, ngemva kokuphela komjikelezo wokukhiqiza, isivundisi kufanele sihlanzwe ngokushesha ngangokunokwenzeka, okuyinto engafaneleki, futhi izohlanzwa futhi ifakwe amagciwane ngaphambi kokusetshenziswa okulandelayo.
1.2.3 Amandla e-scour angenye into enkulu ethinta umphumela wokuhlanza.Kungakhathaliseki ukuthi ipayipi elishisayo noma udonga lwethangi, umphumela wokuhlanza ungcono kuphela lapho uketshezi oluwasha lusesimweni esibucayi.Ngakho-ke, kuyadingeka ukulawula ngempumelelo amandla okuguquguquka kanye nezinga lokugeleza ukuze indawo engaphezulu yedivayisi imanziswe ngokwanele ukuze kuqinisekiswe umphumela omuhle wokuhlanza.
1.2.4 Ukusebenza kwe-ejenti yokuhlanza ngokwayo kuncike ohlotsheni lwayo (i-asidi noma isisekelo), umsebenzi kanye nokugxila.
1.2.5 Ezimweni eziningi, umphumela wokuhlanza ukhuphuka ngokukhuphuka kwezinga lokushisa.Inombolo enkulu yokuhlolwa ibonise ukuthi lapho uhlobo nokugxila kwe-ejenti yokuhlanza kunqunywa, umphumela wokuhlanza ku-50 ° C imizuzu engu-5 nokugeza ku-20 ° C ku-30 min kuyafana.
2 i-fermenter CIP yokuhlanza
Imodi yokusebenza ye-2.1CIP kanye nomthelela wayo kumphumela wokuhlanza
Indlela yokuhlanza ejwayeleke kakhulu esetshenziswa abaphisi botshwala besimanje ukuhlanza endaweni (CIP), okuyindlela yokuhlanza nokubulala amagciwane kanye nokufaka amapayipi ngaphandle kokuqaqa izingxenye noma okokufakwa kwezinto zokusebenza ngaphansi kwezimo ezivaliwe.
2.1.1 Iziqukathi ezinkulu ezifana nezibilisi azikwazi ukuhlanzwa kusetshenziswa isixazululo sokuhlanza.Ukuhlanzwa kwe-in-situ kwe-fermentor kwenziwa ngomjikelezo we-scrubber.I-scrubber inezinhlobo ezimbili zohlobo lokugeza ibhola olungaguquki kanye nohlobo lwe-rotary jet.Uketshezi lokuwasha lufafazwa endaweni engaphakathi yethangi nge-scrubber, bese uketshezi oluwasha lugeleza phansi odongeni lwethangi.Ngaphansi kwezimo ezijwayelekile, uketshezi oluwashayo lwakha ifilimu ehlanganiswe nethangi.Odongeni lwethangi.Umphumela walesi senzo somshini mncane, futhi umphumela wokuhlanza ufezwa ngokuyinhloko isenzo samakhemikhali se-ejenti yokuhlanza.
2.1.2 I-scrubber yohlobo lokuwasha amabhola engashintshi ine-radius yokusebenza engama-2 m.Kuma-fermenters avundlile, kufanele kufakwe ama-scrubber amaningi.Ukucindezela koketshezi lokuwasha endaweni yokuphuma kwe-scrubber nozzle kufanele kube yi-0.2-0.3 MPa;ama-fermenters aqondile Futhi iphoyinti lokulinganisa ingcindezi ekuphumeni kwepompo yokuwasha, hhayi kuphela ukulahlekelwa kwengcindezi okubangelwa ukumelana kwepayipi, kodwa futhi nomthelela wokuphakama ekucindezelweni kokuhlanza.
2.1.3 Uma ingcindezi iphansi kakhulu, i-radius yesenzo ye-scrubber incane, izinga lokugeleza alanele, futhi uketshezi lokuhlanza olufuthiwe alukwazi ukugcwalisa udonga lwethangi;lapho ukucindezela kuphezulu kakhulu, uketshezi lokuhlanza luzokwenza inkungu futhi alukwazi ukwenza ukugeleza okuya phansi eduze kodonga lwethangi.Ifilimu yamanzi, noma uketshezi lokuhlanza olufuthiweyo, luhlehla odongeni lwethangi, lunciphise umphumela wokuhlanza.
2.1.4 Uma okokusebenza okuzohlanzwa kungcolile futhi ububanzi bethangi bukhulu (d>2m), isihlilingi sohlobo lwejethi ejikelezayo ngokuvamile sisetshenziselwa ukukhulisa irediyasi yokuwasha (0.3-0.7 MPa) ukwandisa irediyasi yokuwasha kanye thuthukisa i-radius yokuwasha.Isenzo somshini we-rinse kwandisa umphumela wokwehlisa.
2.1.5 Izihlikihli ze-Rotary jet zingasebenzisa izinga lokugeleza eliphansi le-purge fluid kune-washer yebhola.Njengoba i-rising medium idlula, isihlilingi sisebenzisa i-recoil yoketshezi ukuzungeza, ukushaywa kanye nokukhipha ngokuhlukile, ngaleyo ndlela sithuthukise umphumela wokuhlanza.
2.2 Isilinganiso sokugeleza kwamanzi okuhlanza
Njengoba kushiwo ngenhla, i-fermenter idinga ukuba namandla athile okuguquguquka kanye nezinga lokugeleza lapho ihlanza.Ukuze kuqinisekiswe ukushuba okwanele kwesendlalelo sokugeleza kwamanzi futhi wenze ukugeleza okuqhubekayo okuqhubekayo, kuyadingeka ukunaka izinga lokugeleza kwepompo yokuhlanza.
2.2.1 Kunezindlela ezahlukene zokulinganisa izinga lokugeleza koketshezi lokuhlanza lokuhlanza amathangi angaphansi kwekhoni eliyindilinga.Indlela evamile ibheka kuphela ukuzungeza kwethangi, futhi kunqunywa kububanzi obungu-1.5 kuya ku-3.5 m3/m•h ngokobunzima bokuhlanza (ngokuvamile umkhawulo ophansi wethangi elincane kanye nomkhawulo ongaphezulu wethangi elikhulu. ).Ithangi eliphansi le-cone eliyisiyingi elinobubanzi obungu-6.5m linomjikelezo ongaba ngu-20m.Uma kusetshenziswa i-3m3/m•h, izinga lokugeleza koketshezi lokuhlanza lingaba ngu-60m3/h.
2.2.2 Indlela entsha yokulinganisa isuselwe eqinisweni lokuthi inani lama-metabolite (izinsalela) elincipha ilitha ngalinye lewort epholile ngesikhathi sokuvutshelwa lihlala linjalo.Lapho ububanzi bethangi bukhula, indawo yangaphakathi yendawo yangaphakathi yeyunithi ngayinye umthamo wethangi uyancipha.Ngenxa yalokho, inani lomthwalo wokungcola endaweni ngayinye yeyunithi liyakhula, futhi izinga lokugeleza koketshezi lokuhlanza kufanele lenyuke ngokufanele.Kunconywa ukusebenzisa i-0.2 m3/m2•h.I-fermenter enamandla angu-500 m3 nobubanzi obuyi-6.5 m inendawo yangaphakathi engaba ngu-350 m2, futhi izinga lokugeleza koketshezi lokuhlanza lingaba ngu-70 m3 / h.
Izindlela ezi-3 ezivame ukusetshenziswa kanye nezinqubo zokuhlanza ama-fermenters
3.1 Ngokusho kokushisa kokusebenza kokuhlanza, kungahlukaniswa ukuhlanza okubandayo (ukushisa okuvamile) nokuhlanza okushisayo (ukushisa).Ukuze wonge isikhathi futhi ugeze uketshezi, abantu bavame ukugeza ezingeni lokushisa eliphezulu;ukuze kuphephe ukusebenza kwethangi elikhulu, ukuhlanza okubandayo kuvame ukusetshenziselwa ukuhlanza amathangi amakhulu.
3.2 Ngokohlobo lwe-ejenti yokuhlanza esetshenzisiwe, ingahlukaniswa ibe ukuhlanza okune-asidi nokuhlanzwa kwe-alkaline.Ukugeza nge-alkali kulungele ikakhulukazi ukususa ukungcola okuphilayo okwenziwe ohlelweni, njengemvubelo, amaprotheni, i-hop resin, njll;i-pickling ngokuyinhloko iwukususa izinto ezingcolisa izinto ezingaphili ezikhiqizwa ohlelweni, njengosawoti we-calcium, usawoti we-magnesium, amatshe kabhiya, nokunye okunjalo.
Isikhathi sokuthumela: Oct-30-2020